3-Hydroxypiperidine → HCID 67268684, compound

HRID 2378085Notes

Reaction equation

HRID 2378085 reaction equation
[C:1]1([CH2:11][NH:12][C:13]([C:15]2O[C:17]([NH:20][CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24])=[N:18][N:19]=2)=[O:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[OH:26][CH:27]1[CH2:32][CH2:31][CH2:30][NH:29][CH2:28]1>ClCCl>[OH:26][CH:27]1[CH2:32][CH2:31][CH2:30][N:29]([C:17]2[N:20]([CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24])[C:15]([C:13]([NH:12][CH2:11][C:1]3[C:10]4[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=4)[CH:4]=[CH:3][CH:2]=3)=[O:14])=[N:19][N:18]=2)[CH2:28]1

Participants

4

Reactant 2

HCID 232933-HydroxypiperidineHCID 67268920HCID 67268920, compound

Product 1

HCID 67268684HCID 67268684, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
200 °C

Procedure

A mixture of 0.12 g 5-(3-methyl-but-2-enyl)amino-[1,3,4]oxadiazole-2-carboxylic acid-(naphth-1-ylmethyl)-amide and 1.80 g 3-hydroxypiperidine is stirred for 20 min at 200° C. in a microwave. After cooling to ambient temperature dichloromethane is added, the organic phase is washed once with water and once with 1 M hydrochloric acid, dried over sodium sulphate, and the solvent is removed.

Workup

  1. additionis added
  2. washthe organic phase is washed once with water and once with 1 M hydrochloric acid
  3. dry with materialdried over sodium sulphate
  4. customthe solvent is removed

Sources & evidence

ORD record
ord-a19fb9cb65e946b3b8951582459a01bd
Source dataset
uspto-grants-2008_12
Patent number
US07470716B2

Reaction notes

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