反应详情

Add 2-(thiophen-3-ylaminomethylene)-malonic acid diethyl ester (7.66 g, 28.4 mmol) to refluxing phenyl ether (100 ml) over a period of 5 min under nitrogen. After the addition is complete, keep the reaction under reflux for 30 min. Cool the reaction mixture to room temperature, and then pour it into ethyl acetate (1000 ml). Collect the brown precipitate by filtration to obtain 7-hydroxy-thieno[3,2-b]pyridine-6-carboxylic acid ethyl ester (4.82 g, 76%). MS (ES+): 224 (M+H); (ES−): 222 (M−H).

1. additionAfter the addition
2. customthe reaction
3. temperatureunder reflux for 30 min
4. customCollect the brown precipitate
5. filtrationby filtration