Water → HCID 69205833, compound

HRID 2378300Notes

Reaction equation

HRID 2378300 reaction equation
C(OP([CH2:9][C:10]#[N:11])(=O)OCC)C.C[Si]([N-][Si](C)(C)C)(C)C.[Li+].[O:22]1[C:27]2[CH:28]=[CH:29][C:30]([C:32]([C:34]3[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=3)=O)=[CH:31][C:26]=2[O:25][CH2:24][CH2:23]1.O>C1COCC1>[O:22]1[C:27]2[CH:28]=[CH:29][C:30]([C:32]([C:34]3[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=3)=[CH:9][C:10]#[N:11])=[CH:31][C:26]=2[O:25][CH2:24][CH2:23]1

Participants

6

Reactant 4

HCID 962WaterHCID 75676Diethyl (cyanomethyl)phosphonateHCID 2733832Lithium HexamethyldisilazideHCID 24261598HCID 24261598, compound

Product 1

HCID 69205833HCID 69205833, compoundYield 77.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of cyanomethylphosphonic acid diethyl ester (2.1 mL, 13.5 mmol) in anhydrous THF (15 mL) was added lithium bis(trimethylsilyl)amide (1.0 M solution in THF, 13.5 mL, 13.5 mmol) at 0° C. and stirred for 30 min at room temperature followed by addition of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(3-methoxy-phenyl)-methanone (2.0 g crude, 6.7 mmol) in THF (15 mL) and refluxed for 30 min. The reaction mixture was poured into water (50 mL), extracted with CH2Cl2 (2×50 mL). The combined organic phases were washed with brine (50 mL), dried over MgSO4, and purified via flash column chromatography (EtOAc, Hexane) to give 3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-(3-methoxy-phenyl)-acrylonitrile as an off-white solid (1.53 g, 77% yield): mp, 64-66° C.; 1H NMR (DMSO-d6) δ 3.77 and 3.78 (2s, 3H, OCH3), 4.24-4.36 (m, 4H, CH2CH2), 6.19 and 6.24 (2s, 1H, CH), 6.77-7.09 (m, 6H, Ar), 7.33-7.36 (m, 1H, Ar); 13C NMR (DMSO-d6) δ 55.2, 55.2, 64.0, 64.0, 64.2, 64.3, 94.3, 95.2, 113.7, 114.6, 114.9, 115.8, 116.7, 117.1, 117.2, 117.9, 118.3, 120.9, 121.2, 121.7, 122.5, 129.7, 129.8, 129.8, 130.6, 138.5, 139.7, 143.1, 143.3, 144.8, 145.6, 159.1, 159.2, 160.8, 160.9. Anal. Calcd for C18H15NO3: C, 73.71; H, 5.15; N, 4.78. Found: C, 73.48; H, 4.84; N, 4.64.

Workup

  1. temperaturerefluxed for 30 min
  2. extractionextracted with CH2Cl2 (2×50 mL)
  3. washThe combined organic phases were washed with brine (50 mL)
  4. dry with materialdried over MgSO4
  5. custompurified via flash column chromatography (EtOAc, Hexane)

Sources & evidence

ORD record
ord-d843e1e95df447d4b2f661a96f16b89c
Source dataset
uspto-grants-2008_12
Patent number
US07470723B2

Reaction notes

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