Hydrochloric Acid → 1-Chloro-2-iodo-4-nitrobenzene

Temperature

0 °C

2-amino-5-nitro-iodobenzene (10.00 g, 37.9 mmol) was suspended in 12 N HCl (25 mL) and water (40 mL) and stirred for 30 min at 22° C. The mixture was then cooled to 0° C. and NaNO2 (5.23 g, 75.8 mmol in 18 mL of H2O) was added over a 10 min period. After 1 h, this solution was transferred to a solution of CuCl (3.75 g, 37.9 mmol) in water (50 mL) at 60° C. After 2 h, the mixture was cooled to 22° C. and extracted with EtOAc (3×150 mL) and the organics were dried over anhydrous MgSO4. The crude product was purified by silica gel flash chromatography eluting with 10-20% CH2Cl2 in hexanes to give compound 801A (4.20 g) as a yellow solid. HPLC: 100% at 3.447 min (retention time) (YMC S5 ODS column 4.6×50 mm eluting with 10-90% aqueous methanol over 4 mincontaining 0.2% phosphoric acid, 4 mL/min, monitoring at 220 nm).

1. waitAfter 2 h
2. temperaturethe mixture was cooled to 22° C.
3. extractionextracted with EtOAc (3×150 mL)
4. dry with materialthe organics were dried over anhydrous MgSO4
5. customThe crude product was purified by silica gel flash chromatography
6. washeluting with 10-20% CH2Cl2 in hexanes

ORD record

ord-abdc921450574455992fc58d7cbceb8d

Source dataset

uspto-grants-2008_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07470797B2