Ethyl 3-(3-fluoro-4-methyloxyphenyl)Acrylate → HCID 22558762, compound

HRID 2378530Notes

Reaction equation

HRID 2378530 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]>C(OCC)(=O)C.CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

5

Reactant 1

HCID 53705486Ethyl 3-(3-fluoro-4-methyloxyphenyl)Acrylate

Product 1

HCID 22558762HCID 22558762, compoundYield 99.4%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of Intermediate 7 (3.01 g) in ethyl acetate (50 ml) and methanol (25 ml) was added with 10% palladium/carbon (300 mg, Merck), and stirred at room temperature for 2 hours under hydrogen atmosphere. The reaction mixture was filtered, and the solvent of the filtrate was evaporated under reduced pressure to obtain the title compound (Intermediate 8, 3.02 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-3cec7341f3274df9a0847e009ebb01c9
Source dataset
uspto-grants-2008_12
Patent number
US07470807B2

Reaction notes

Loading…