HCID 86614983, compound → HCID 86614982, compound

HRID 2378549Notes

Reaction equation

HRID 2378549 reaction equation
C([O:8][C:9]1[C:14]([NH:15][C:16](=[O:21])[C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[CH:11][C:10]=1[C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][CH:36]=1)[N:33]([CH3:37])[N:32]=[CH:31]2)C1C=CC=CC=1>C(OCC)(=O)C.CO.[Pd]>[OH:8][C:9]1[C:14]([NH:15][C:16](=[O:21])[C:17]([F:18])([F:19])[F:20])=[CH:13][C:12]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[CH:11][C:10]=1[C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][CH:36]=1)[N:33]([CH3:37])[N:32]=[CH:31]2

Participants

5

Reactant 1

HCID 86614983HCID 86614983, compound

Product 1

HCID 86614982HCID 86614982, compoundYield 89.2%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of Intermediate 56 (1.62 g) in a mixture of ethyl acetate (10 ml) and methanol (3 ml) was added with 10% palladium/carbon (29 mg), and stirred at room temperature for 17 hours under hydrogen atmosphere. The reaction mixture was filtered, and the solvent of the filtrate was evaporated under reduced pressure to obtain the title compound (Intermediate 57, 1.19 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-cb24740bc17648e0b61ad1134497d146
Source dataset
uspto-grants-2008_12
Patent number
US07470807B2

Reaction notes

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