Methyl iodide → HCID 178483384, compound

HRID 2378711Notes

Reaction equation

HRID 2378711 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1)[CH3:3].[CH3:14][I:15]>C(OCC)(=O)C>[I-:15].[NH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]([CH2:4][N+:2]([CH3:14])([CH3:1])[CH3:3])=[N:6]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178483331(1H-Indazol-3-yl)-N,N-dimethylmethanamine

Product 1

HCID 178483384HCID 178483384, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

3-Dimethylaminomethyl-1H-indazole (25.6 g, 146 mmol) obtained in Step 2 was dissolved in ethyl acetate (350 mL), and the solution was added with methyl iodide (33.3 mL, 535 mmol), followed by stirring at room temperature overnight. The resulting precipitates were collected by filtration to obtain (1H-indazol-3-ylmethyl)trimethylammonium iodide (45.0 g, 97%).

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-9d51dc26137e4f4caa4ab489dba6e440
Source dataset
uspto-grants-2008_12
Patent number
US07470717B2

Reaction notes

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