2-Bromoethyl ethyl ether → 1-(2-Ethoxyethyl)-4-cyano-4-phenyl-piperidine

HRID 2379035Notes

Reaction equation

HRID 2379035 reaction equation
[C:1]([C:3]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)#[N:2].[CH2:15]([O:17][CH2:18][CH2:19]Br)[CH3:16]>>[CH2:15]([O:17][CH2:18][CH2:19][N:6]1[CH2:5][CH2:4][C:3]([C:1]#[N:2])([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)[CH3:16]

Participants

3

Reactant 2

HCID 611412-Bromoethyl ethyl etherHCID 1811384-Piperidinecarbonitrile, 4-phenyl-

Product 1

HCID 189578131-(2-Ethoxyethyl)-4-cyano-4-phenyl-piperidine

Procedure

The title compound was prepared as described in Example I 2 from 4-cyano-4-phenylpiperidine and 2-bromoethyl ethyl ether excluding KI: Reaction time under reflux 6 hours. The compound boiled at 130°-135°/0.005 mm Hg.

Workup

  1. customReaction time
  2. temperatureunder reflux 6 hours

Sources & evidence

ORD record
ord-81ecb32af180451fae4732884ef92266
Source dataset
uspto-grants-1994_11
Patent number
US05360805

Reaction notes

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