反应详情

7.58 g of potassium carbonate and 6.02 g of N-carboethoxyphthalimide were added to 180 ml of an aqueous solution of 6.01 g of 3-nitrotyramine hydrochloride and stirred for 15 hours at room temperature. 6N hydrochloric acid was gradually added to the reaction mixture at 0° C. so that the pH value of the mixture was adjusted to be 1 (one). The crystals thus precipitated out were removed by means of filtration and recrystallized from methanol to obtain 7.79 g (yield: 91%) of 4-[2-(phthalimido)ethyl]-2-nitrophenol as yellow crystals.

1. customThe crystals thus precipitated out
2. customwere removed by means of filtration
3. customrecrystallized from methanol