Hydrazine hydrate (1:1) → HCID 18958317, compound

HRID 2379273Notes

Reaction equation

HRID 2379273 reaction equation
O.NN.C1(=O)[N:8]([CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][C:14]([O:15][CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[C:13]([N+:26]([O-:28])=[O:27])[CH:12]=2)C(=O)C2=CC=CC=C12>C(O)C>[NH2:8][CH2:9][CH2:10][C:11]1[CH:25]=[CH:24][C:14]([O:15][CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[C:13]([N+:26]([O-:28])=[O:27])[CH:12]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18958324HCID 18958324, compound

Product 1

HCID 18958317HCID 18958317, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
100 °C

Procedure

5 ml of ethanol solution of 1.02 g of hydrazine hydrate were added to 35 ml of ethanol solution of 4.36 g of t-butyl 4-[2-(phthalimido)ethyl]-2-nitrophenoxyacetate and heated under reflux for 2 hours at 100° C. in an argon stream. After cooling, the reaction mixture was filtered through celite, and the filtrate concentrated under reduced pressure. The yellow crystals of t-butyl 4-(2-aminoethyl)-2-nitrophenoxyacetate thus obtained were used in the next reaction without purification.

Workup

  1. temperatureheated
  2. temperatureAfter cooling
  3. filtrationthe reaction mixture was filtered through celite
  4. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-5ae23e09163d4af296a1cda105a2e41b
Source dataset
uspto-grants-1994_11
Patent number
US05360909

Reaction notes

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