Water → HCID 18955755, compound

HRID 2379657Notes

Reaction equation

HRID 2379657 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([OH:30])=O)=[CH:24][CH:23]=2)=[CH:18][CH:17]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[OH2:31].[O:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH2:7]([O:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:23]=[CH:24][C:25]([CH2:28][O:30][C:7]3[CH:8]=[CH:9][C:35]([C:36]([O:32][CH:21]([CH3:20])[CH2:16][CH2:17][CH2:18][CH3:19])=[O:31])=[CH:34][CH:33]=3)=[CH:26][CH:27]=2)=[CH:20][CH:21]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

5

Reactant 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 28025564'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acidHCID 21226445Aluminium lithium hydride

Product 1

HCID 18955755HCID 18955755, compoundYield 95%

Procedure

Lithium aluminium hydride (5.3 mmols) was suspended in 38 ml of tetrahydrofuran, and 3.1 mmols of 4'-octyloxybiphenyl-4-carboxylic acid were slowly added. After stirring at room temperature for 2 hours, the reaction mixture was charged into a large amount of water, and extracted with dichloromethane. After the extract was dried over anhydrous sodium sulfate, the solvent was evaporated to obtain a final product. Since said product showed 1 spot in thin layer chromatography, it was used in the next step without purification. The yield was 95%.

Workup

  1. extractionextracted with dichloromethane
  2. dry with materialAfter the extract was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-07c2d0c86c7c40888e60b1f2af1334f5
Source dataset
uspto-grants-1994_11
Patent number
US05364560

Reaction notes

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