HRID2379707

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1

HCID3822

Ketanserin

C22H22FN3O3

结构：Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1

HCID5074

Ritanserin

C27H25F2N3OS

结构：O=C(CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc(F)cc1

HCID5265

Spiperone

C23H26FN3O2

结构：O=c1[nH]c2ccccc2c(=O)n1CCCN1CCN(c2ccccc2)CC1

HCID65435

Pelanserin

C21H24N4O2

PRODUCTS

生成物

结构：NC(=O)C1(N2CCCCC2)CCN(CCCC(=O)c2ccc(F)cc2)CC1

HCID4830

Pipamperone

C21H30FN3O2

PROCEDURE

实验过程

4-phenyl-8-[3-(4-fluorobenzoyl)propyl]-1-oxo-2,4,8-triazaspiro[4,5]decane (INN:spiperone), 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]-ethyl]-2,4-[1H, 3H]-quinazolinedione (INN: ketanserin), pirenperin (INN), ritanserin (INN) and pelanserin (INN).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ffc704515dd34770a4e26e061a40fdef
来源数据集: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05364857
来源说明: uspto-grants-1994_11

反应 SMILES

[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][C:20](=[O:28])[C:21]4[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=4)[CH2:13][CH2:12]3)[C:10](=[O:29])[NH:9]C2)C=[CH:5][CH:4]=[CH:3][CH:2]=1.FC1C=CC(C(C2CCN(CCN3C(=O)C4C(=CC=CC=4)NC3=O)CC2)=O)=CC=1.CC1N=C2N(C=CS2)C(=O)C=1CCN1CCC(=C(C2C=CC(F)=CC=2)C2C=CC(F)=CC=2)CC1.C1C=CC(N2CCN(CCCN3C(=O)NC4C=CC=CC=4C3=O)CC2)=CC=1>>[F:27][C:24]1[CH:25]=[CH:26][C:21]([C:20](=[O:28])[CH2:19][CH2:18][CH2:17][N:14]2[CH2:15][CH2:16][C:11]([N:7]3[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5]3)([C:10](=[O:29])[NH2:9])[CH2:12][CH2:13]2)=[CH:22][CH:23]=1