Methanol → HCID 67820999, compound

HRID 2379810Notes

Reaction equation

HRID 2379810 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[N:11]=[C:10]([C:12]2[N:13]=[C:14]([NH:17][C:18]([NH2:20])=[S:19])[S:15][CH:16]=2)[CH:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[CH3:21][I:22].CO>O1CCCC1>[IH:22].[C:1]([NH:4][CH2:5][C:6]1[N:11]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[S:19][CH3:21])[S:15][CH:16]=2)[CH:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 887MethanolHCID 6328Methyl iodideHCID 11045018HCID 11045018, compound

Product 1

HCID 67820999HCID 67820999, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 4-(6-acetylaminomethylpyridin-2-yl)-2-thioureidothiazole (5.3 g) and methyl iodide (1.2 ml) in a solution of methanol (53 ml) and tetrahydrofuran (25 ml) was heated under reflux for 4.5 hours. The solvent was removed by concentration in vacuo and resulting residue was triturated with ethyl acetate to give 4-(6-acetylaminomethylpyridin-2-yl)-2-[(amino)(methylthio)methyleneamino]thiazole hydriodide.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 4.5 hours
  3. customThe solvent was removed by concentration in vacuo
  4. customresulting residue
  5. customwas triturated with ethyl acetate

Sources & evidence

ORD record
ord-74120bf9e1fc494bbe420b37835d69a2
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

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