Hydrochloric Acid → HCID 18956299, compound

HRID 2379828Notes

Reaction equation

HRID 2379828 reaction equation
[ClH:1].[C:2]([NH:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([NH2:17])[S:15][CH:16]=2)[N:11]=1)(=[O:4])[CH3:3].C(OC(C)C)(C)C>CO>[ClH:1].[C:2]([NH:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([NH2:17])[S:15][CH:16]=2)[N:11]=1)(=[O:4])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 18956300HCID 18956300, compound

Product 1

HCID 18956299HCID 18956299, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4N-Dioxanoic hydrogen chloride (10 ml) was added to a suspension of 4-(2-acetylaminomethylthiazol-4-yl)-2-aminothiazole (0.75 g) in methanol (30 ml). The mixture was stirred at room temperature for 40 minutes, and diisopropyl ether (50 ml) was added. The resulting precipitate was collected by filtration. Recrystallization from a mixture of methanol and dioxane afforded 4-(2-acetylaminomethylthiazol-4-yl)-2-aminothiazole hydrochloride (0.35 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customRecrystallization
  3. additionfrom a mixture of methanol and dioxane

Sources & evidence

ORD record
ord-df8f0a8e7ba44abc837413f210993443
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

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