Methanol → HCID 178484928, compound

HRID 2379829Notes

Reaction equation

HRID 2379829 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[N:11]=[C:10]([C:12]2[N:13]=[C:14]([NH:17][C:18]([NH:20][CH3:21])=[S:19])[S:15][CH:16]=2)[CH:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[CH3:22][I:23].CO>O1CCCC1>[IH:23].[C:1]([NH:4][CH2:5][C:6]1[N:11]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH:20][CH3:21])[S:19][CH3:22])[S:15][CH:16]=2)[CH:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 887MethanolHCID 6328Methyl iodideHCID 54166508HCID 54166508, compound

Product 1

HCID 178484928HCID 178484928, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 4-(6-acetylaminomethylpyridin-2-yl)-2-(3-methylthioureido)thiazole (1.5 g) and methyl iodide (0.45 ml) in a solution of methanol (15 ml) and tetrahydrofuran (8 ml) was heated under reflux for 9 hours. The solvent was removed by concentration and the residue was triturated with ethyl acetate to give 4-(6-acetylaminomethylpyridin-2-yl)-2-[(methylamino)(methylthio)methyleneamino]thiazole hydriodide (1.44 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 9 hours
  3. customThe solvent was removed by concentration
  4. customthe residue was triturated with ethyl acetate

Sources & evidence

ORD record
ord-e9c99baa233145b0bb09c80ed4471e12
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

Loading…