Hydrazine hydrate (1:1) → HCID 70043352, compound

HRID 2380065Notes

Reaction equation

HRID 2380065 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:28])([CH:16]([C:18]1[CH:23]=[CH:22][N:21]=[C:20]([C:24]([O:26]C)=O)[CH:19]=1)[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.O.[NH2:30][NH2:31]>C(O)(C)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:28])([CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1)[CH:16]([C:18]1[CH:23]=[CH:22][N:21]=[C:20]([C:24]([NH:30][NH2:31])=[O:26])[CH:19]=1)[CH3:17]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19896865HCID 19896865, compound

Product 1

HCID 70043352HCID 70043352, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of the product of part (i) (3.80 g) and hydrazine hydrate (6.0 ml) in isopropanol (20 ml) was heated under reflux for 2.5 hours and then evaporated. Water was added to the residue and the mixture was extracted several times with dichloromethane. The combined extracts were washed with brine and dried (MgSO4). Evaporation of the solvent gave the title compound (3.30 g) as an amorphous foam which was used directly in the next stage.

Workup

  1. temperatureunder reflux for 2.5 hours
  2. customevaporated
  3. additionWater was added to the residue
  4. extractionthe mixture was extracted several times with dichloromethane
  5. washThe combined extracts were washed with brine
  6. dry with materialdried (MgSO4)
  7. customEvaporation of the solvent

Sources & evidence

ORD record
ord-22d9fab754fd4f0bafa5260d649aa3ee
Source dataset
uspto-grants-1994_11
Patent number
US05364938

Reaction notes

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