反应详情

温度

150 °C

Ethylamine (0.7 g) was added to a solution of N-(2-bromo-6-methoxy-3-pyridinyl)-2-chloro-N-methyl-3-pyridinecarboxamide (1.9 g) in xylene (5 ml), and the resulting mixture was sealed in a pressure bottle and heated at 150° C. for 4 hours. The solution was diluted with ethyl acetate, washed with water, dried (anhydrous magnesium sulfate), concentrated, and purified on a silica gel column (ethyl acetate/hexane, 1:4) to give 1.5 g of the title compound, suitable for use in the next reaction.

1. customthe resulting mixture was sealed in a pressure bottle
2. washwashed with water
3. dry with materialdried (anhydrous magnesium sulfate)
4. concentrationconcentrated
5. custompurified on a silica gel column (ethyl acetate/hexane, 1:4)