Hydrochloric Acid → HCID 136156080, compound

HRID 2380285Notes

Reaction equation

HRID 2380285 reaction equation
C([N:3]1[C:10]2[N:6]([N:7]=[CH:8][C:9]=2[C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:5][CH2:4]1)=O.Cl.C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:14]([O:13][C:11]([C:9]1[CH:8]=[N:7][N:6]2[CH2:5][CH2:4][NH:3][C:10]=12)=[O:12])[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 18955287HCID 18955287, compound

Product 1

HCID 136156080HCID 136156080, compoundYield 96.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 1-formyl-2,3-dihydro-7-ethoxycarbonyl-1H-imidazo[1,2-b]pyrazole (40 g) in methanol (200 ml) was added conc. hydrochloric acid (31.9 ml) under ice-cooling. The mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into ice-water (300 ml) and adjusted to pH 6.5 with 40% aqueous potassium carbonate solution. The mixture was evaporated to precipitate the crystals. The crystals were collected by filtration to give 2,3-dihydro-7-ethoxycarbonyl-1H-imidazo[1,2-b]pyrazole (33.4 g).

Workup

  1. temperaturecooling
  2. customThe mixture was evaporated
  3. customto precipitate the crystals
  4. filtrationThe crystals were collected by filtration

Sources & evidence

ORD record
ord-ae5d51d90c6a424d975975618d3f7ce2
Source dataset
uspto-grants-1994_11
Patent number
US05366970

Reaction notes

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