Hydrochloric Acid → HCID 131717687, compound

HRID 2380296Notes

Reaction equation

HRID 2380296 reaction equation
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7](=[N:33][O:34][CH2:35][CH:36]=[CH2:37])[C:8]([NH:10][C@@H:11]2[C:31](=[O:32])[N:13]3[C:14]([C:28]([O-:30])=[O:29])=[C:15]([CH2:18][N+:19]4[N:23]5[CH2:24][CH2:25][CH2:26][NH:27][C:22]5=[CH:21][CH:20]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1.[ClH:38]>O>[ClH:38].[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7](=[N:33][O:34][CH2:35][CH:36]=[CH2:37])[C:8]([NH:10][C@@H:11]2[C:31](=[O:32])[N:13]3[C:14]([C:28]([O-:30])=[O:29])=[C:15]([CH2:18][N+:19]4[N:23]5[CH2:24][CH2:25][CH2:26][NH:27][C:22]5=[CH:21][CH:20]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131717689HCID 131717689, compound

Product 1

HCID 131717687HCID 131717687, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-allyloxyiminoacetamido]-3-(4,5,6,7-tetrahydro-1-pyrazolo[1,5-a]pyrimidinio)methyl-3-cephem-4-carboxylate (syn isomer) (1 g) in water (3 ml) was added 2N hydrochloric acid (1 ml) at room temperature. The mixture was stirred at ambient temperature for 3 hours, and the resulting precipitate was collected by filtration to give 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-allyloxyiminoacetamido]-3-(4,5,6,7-tetrahydro-1-pyrazolo[1,5-a]pyrimidinio)methyl-3-cephem-4-carboxylate hydrochloride (syn isomer) (202 mg) as crystals.

Workup

  1. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-face205e01ab4e81908455c239d0c3a9
Source dataset
uspto-grants-1994_11
Patent number
US05366970

Reaction notes

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