Triethylamine → HCID 15219348, compound

HRID 2380300Notes

Reaction equation

HRID 2380300 reaction equation
C([N:3]([CH2:6][CH3:7])CC)C.[F:8][C:9]([F:26])([F:25])[O:10][CH:11]([F:24])[C:12]([F:23])([F:22])[O:13]NCC1C=CC=CC=1.[Cl:27][C:28]1[C:29]([CH2:37][CH3:38])=[N:30][N:31]([CH3:36])[C:32]=1[C:33](Cl)=[O:34]>C(Cl)Cl>[Cl:27][C:28]1[CH:32]=[C:7]([CH:38]=[CH:37][C:29]=1[O:13][C:12]([F:22])([F:23])[CH:11]([O:10][C:9]([F:8])([F:25])[F:26])[F:24])[CH2:6][NH:3][C:33]([C:32]1[N:31]([CH3:36])[N:30]=[C:29]([CH2:37][CH3:38])[C:28]=1[Cl:27])=[O:34]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 450819144-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carbonyl chlorideHCID 86748271HCID 86748271, compound

Product 1

HCID 15219348HCID 15219348, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture consisting of 2 ml of methylene chloride, 0.11 ml of triethylamine and 250 mg of 3-chloro-4-((2-trifluoromethoxy-1,1,2-trifluoroethoxy)-benzylamine (0.77 moles) is slowly added dropwise to a solution of 166 mg (0.8 mmoles) of 4-chloro-3-ethyl-1-methyl-5-pyrazolecarboxylic acid chloride in 3 ml of methylene chloride. The solution obtained is maintained under agitation at ambient temperature for 5 hours.

Workup

  1. customThe solution obtained

Sources & evidence

ORD record
ord-2eccc92e1836406e9facd96dfab536a4
Source dataset
uspto-grants-1994_11
Patent number
US05366991

Reaction notes

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