Triethylamine → HCID 53841370, compound

HRID 2380301Notes

Reaction equation

HRID 2380301 reaction equation
C([N:3]([CH2:6][CH3:7])CC)C.[F:8][C:9]([F:26])([F:25])[O:10][CH:11]([F:24])[C:12]([F:23])([F:22])[O:13]NCC1C=CC=CC=1.[Cl:27][C:28]1[C:29]([CH2:37][CH3:38])=[N:30][N:31]([CH3:36])[C:32]=1[C:33](Cl)=[O:34]>C(Cl)Cl>[F:26][C:9]([F:8])([F:25])[O:10][CH:11]([F:24])[C:12]([F:22])([F:23])[O:13][C:28]1[CH:29]=[CH:37][C:7]([CH2:6][NH:3][C:33]([C:32]2[N:31]([CH3:36])[N:30]=[C:29]([CH2:37][CH3:38])[C:28]=2[Cl:27])=[O:34])=[CH:33][CH:32]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 450819144-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carbonyl chlorideHCID 86748271HCID 86748271, compound

Product 1

HCID 53841370HCID 53841370, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture consisting of 4 ml of methylene chloride, 0.22 ml of triethylamine and 450 mg of 4-((2-trifluoromethoxy-1,1,2-trifluoroethoxy)-benzylamine (1.56 moles) is slowly added dropwise to a solution of 332 mg (1.6 mmoles) of 4-chloro-3-ethyl-1-methyl-5-pyrazolecarboxylic acid chloride in 6 ml of methylene chloride. The solution obtained is maintained under agitation at ambient temperature for 4 hours.

Workup

  1. customThe solution obtained

Sources & evidence

ORD record
ord-6ad40c4235724cd3852d578898d81882
Source dataset
uspto-grants-1994_11
Patent number
US05366991

Reaction notes

Loading…