HCID 24866633, compound → HCID 178424208, compound

HRID 238040Notes

Reaction equation

HRID 238040 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[N:6]1)(C)(C)C>C(O)=O.Cl>[C:16]1([CH3:21])[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:7]1[C:8]2[C:9](=[N:10][CH:11]=[N:12][C:13]=2[NH2:14])[NH:5][N:6]=1

Participants

4

Reactant 1

HCID 24866633HCID 24866633, compound

Product 1

HCID 178424208HCID 178424208, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-o-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine was dissolved in a solution of formic acid (2 mL) and conc. HCl (0.2 mL) and heated to reflux for 30 min. Reaction was concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 226.1, found 226.3.

Workup

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. customReaction
  4. concentrationwas concentrated in vacuo
  5. custompurified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-812cd83691384435bea30c2c05e006c7
Source dataset
uspto-grants-2014_02
Patent number
US08642604B2

Reaction notes

Loading…