反应详情

To a mixture of 2-amino-5-(4-nitrophenylsulfonyl)thiazole (4.0 g) and ammonium chloride in a mixture of ethanol (80 ml), tetrahydrofuran (40 ml) and water (30 ml) was portionwise added the iron powder (4 g) at 80° C. with stirring. The mixture was refluxed for 1.5 hours with stirring. The reaction mixture was filtered by suction and the filtrate was concentrated under reduced pressure. The residue was triturated with water and the precipitates were collected by filtration, washed with water and dried in vacuo no give 2-amino-5-(4-aminophenylsulfonyl)thiazole (3.10 g, yield: 86.6%).

1. temperatureThe mixture was refluxed for 1.5 hours
2. stirringwith stirring
3. filtrationThe reaction mixture was filtered by suction
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was triturated with water
6. filtrationthe precipitates were collected by filtration
7. washwashed with water