Hydrochloric Acid → HCID 68496391, compound

HRID 238067Notes

Reaction equation

HRID 238067 reaction equation
[S:1]1[C:5]([C:6]2[C:7]([O:16][C@H:17]3[CH2:54][N:20]4[C:21](=[O:53])[C@@H:22]([NH:45]C(=O)OC(C)(C)C)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH:28]=[CH:29][C@@H:30]5[CH2:35][C@@:31]5([C:36](=[O:44])[NH:37][S:38]([CH:41]5[CH2:43][CH2:42]5)(=[O:40])=[O:39])[NH:32][C:33](=[O:34])[C@@H:19]4[CH2:18]3)=[N:8][C:9]3[C:14]([N:15]=2)=[CH:13][CH:12]=[CH:11][CH:10]=3)=[CH:4][C:3]2[CH:55]=[CH:56][CH:57]=[CH:58][C:2]1=2.[ClH:59]>C(OCC)(=O)C.O1CCOCC1>[ClH:59].[NH2:45][C@@H:22]1[C:21](=[O:53])[N:20]2[CH2:54][C@H:17]([O:16][C:7]3[C:6]([C:5]4[S:1][C:2]5[CH:58]=[CH:57][CH:56]=[CH:55][C:3]=5[CH:4]=4)=[N:15][C:14]4[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=4)[N:8]=3)[CH2:18][C@H:19]2[C:33](=[O:34])[NH:32][C@:31]2([C:36]([NH:37][S:38]([CH:41]3[CH2:42][CH2:43]3)(=[O:39])=[O:40])=[O:44])[CH2:35][C@H:30]2[CH:29]=[CH:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67984286HCID 67984286, compound

Product 1

HCID 68496391HCID 68496391, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

The product of Example 18 (0.296 g, 0.357 mmol) was dissolved in a mixture of ethyl acetate (1.7 mL) and 4 N HCl in dioxane (1.7 mL) and stirred at room temperature for one hour. The mixture was then evaporated under reduced pressure to provide the title compound (0.262 mg, 96% yield).

Workup

  1. customThe mixture was then evaporated under reduced pressure

Sources & evidence

ORD record
ord-85b86bd2cf064237b948fb6352f1c73e
Source dataset
uspto-grants-2014_02
Patent number
US08642538B2

Reaction notes

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