反应详情

温度

25 °C

To a suspension of 2-Benzyl-malonic acid monoethyl ester (150 mg, 0.67 mmol) and 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.74 mmol) in DMF (4 mL) at 25° C. was added 4-phenyl-thiazol-2-ylamine (119 mg, 0.67 mmol), the resulting mixture was stirring at 25° C. for overnight and concentrated in vacuo, and the residue was dissolved in CH2Cl2 (20 mL) was washed with 5% NaHCO3, dried with MgSO4 and concentrated in vacuo. The residue was purified by HPLC. The product was obtained 170 mg (67%) as white solid.

1. concentrationconcentrated in vacuo
2. dissolutionthe residue was dissolved in CH2Cl2 (20 mL)
3. washwas washed with 5% NaHCO3
4. dry with materialdried with MgSO4
5. concentrationconcentrated in vacuo
6. customThe residue was purified by HPLC
7. customThe product was obtained 170 mg (67%) as white solid