Potassium Carbonate → HCID 21081013, compound

HRID 2380827Notes

Reaction equation

HRID 2380827 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N:9]([CH3:11])[CH3:10])=[CH:4][N:3]=1.Cl.Cl.[NH:14]1[C:18]2[CH2:19][CH2:20][CH2:21][NH:22][C:17]=2[N:16]=[CH:15]1.C(=O)([O-])[O-].[K+].[K+]>C(O)(C)C.O>[Cl:1][C:2]1[N:7]=[C:6]([N:22]2[CH2:21][CH2:20][C:19]3[N:16]=[CH:15][NH:14][C:18]=3[CH2:17]2)[C:5]([N:9]([CH3:11])[CH3:10])=[CH:4][N:3]=1

Participants

6

Reactant 3

HCID 11430Potassium Carbonate2×HCID 2555542,4-Dichloro-N,N-dimethylpyrimidin-5-amineHCID 68845019HCID 68845019, compound2×

Product 1

HCID 21081013HCID 21081013, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Conditions

Temperature
25 °C

Procedure

5 g of 2,4-dichloro-5-dimethylamino-pyrimidine are dissolved in 30 mL isopropanol and combined with 5.82 g 4,5,6,7-tetrahydroimidazopyridine dihydrochloride and 6.06 g potassium carbonate. After 6 and 8 days in each case 1 g of 4,5,6,7-tetrahydroimidazopyridine dihydrochloride and 1 g potassium carbonate are added. In all, the mixture is stirred for 10 days at 25° C. The reaction mixture is diluted with 400 mL water and stirred for 1 h. The precipitate formed is suction filtered, washed and dried.

Workup

  1. stirringstirred for 1 h
  2. customThe precipitate formed
  3. filtrationfiltered
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-912dcad25fca4411b4d55a4c81684d13
Source dataset
uspto-grants-2012_09
Patent number
US08258129B2

Reaction notes

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