Hydrochloric Acid → HCID 57819764, compound

HRID 2380828Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][C:11]3[N:14]=[CH:15][NH:16][C:10]=3[CH2:9]2)[C:5]([N:17]([CH3:19])[CH3:18])=[CH:4][N:3]=1.O.Cl.[CH3:22][N:23]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=1)[CH3:24]>O1CCOCC1.CN(C=O)C>[CH3:24][N:23]([CH2:25][C:26]1[CH:27]=[CH:28][C:29]([NH:32][C:2]2[N:7]=[C:6]([N:8]3[CH2:13][CH2:12][C:11]4[N:14]=[CH:15][NH:16][C:10]=4[CH2:9]3)[C:5]([N:17]([CH3:19])[CH3:18])=[CH:4][N:3]=2)=[CH:30][CH:31]=1)[CH3:22]

Participants

Conditions

Temperature: 95 °C

Procedure

50 mg 2-chloro-4-(3,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-5-dimethylamino-pyrimidine are suspended in 60 μL of 1,4-dioxane, 20 μL water and 90 μL of a 5 M hydrochloric acid (in 1,4-dioxane) and mixed with 55 mg 4-dimethylaminomethyl-phenylamine. This mixture is heated to 95° C. and stirred for 20 h at this temperature. The suspension obtained is diluted with DMF and then purified by column chromatography. The carrier material used is C18-RP-silica gel and a gradient is run through which consists at the starting point of 95% water (10 mM ammonium hydrogen carbonate and 38 mM ammonia) and 5% acetonitrile and at the finishing point of 50% water and 50% acetonitrile. The fractions are freeze-dried. The residue is taken up in acetonitrile, combined with aqueous hydrochloric acid and freeze-dried once more.

Workup

customThe suspension obtained
custompurified by column chromatography
customThe fractions are freeze-dried
customfreeze-dried once more

Sources & evidence

ORD record: ord-de4459fe418c4107ab0138afcc27f787
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08258129B2

Reaction notes

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