反应详情

温度

25 °C

A solution of 4,5-dichloro-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (Intermediate 20, 60.0 g, 0.24 mol) in acetone (600 mL) was treated with potassium carbonate (28.4 g, 0.21 mol), tetrabutylammonium bromide (1.2 g), potassium iodide (38.4 g, 0.23 mol) and 1-(2-hydroxy-phenyl)-ethanone (38.4 g, 0.28 mol). The resulting reaction mixture was stirred at 25° C. for 120 h. After this time, the reaction was filtered. The filtrate was concentrated in vacuo. Silica gel column chromatography (1:10 ethyl acetate/petroleum ether) afforded 5-(2-acetyl-phenoxy)-4-chloro-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (15 g, 18%).

1. customThe resulting reaction mixture
2. filtrationAfter this time, the reaction was filtered
3. concentrationThe filtrate was concentrated in vacuo