HCID 86636612, compound → HCID 44467020, compound

HRID 2381626Notes

Reaction equation

HRID 2381626 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[N:22]=[C:21]([N:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]4[CH2:29][NH:30]C(=O)OC(C)(C)C)[C:20]([F:38])=[CH:19][N:18]=3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C(O)(C(F)(F)F)=O>[NH2:30][CH2:29][CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][N:23]1[C:21]1[C:20]([F:38])=[CH:19][N:18]=[C:17]([NH:16][C:13]2[CH:12]=[CH:11][C:10]([N:7]3[CH2:8][CH2:9][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6]3)=[CH:15][CH:14]=2)[N:22]=1

Participants

3

Reactant 1

HCID 86636612HCID 86636612, compound

Product 1

HCID 44467020HCID 44467020, compoundYield 74.4%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl (1-(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-2-yl)methylcarbamate (56 mg, 0.11 mmol) in TFA (3 mL) was stirred at room temperature for 60 min. TFA was removed in vacuo. The residue was purified by HPLC to give the titled compound (35 mg) MS 428.4 (M+H); UV 213.8, 258.8 nm.

Workup

  1. customTFA was removed in vacuo
  2. customThe residue was purified by HPLC

Sources & evidence

ORD record
ord-5c5643205cd046bab1b0949b9cdb9b74
Source dataset
uspto-grants-2012_09
Patent number
US08258144B2

Reaction notes

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