反应详情

To a suspension of 1 ethyl 2-(6-nitro-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetate in EtOH (10 mL) and H2O (5 mL) was added ammonium formate (1.5 g, 23.8 mmol) and Fe (0.3 g, 5.4 mmol). After stirring at reflux for 2 h, the black mixture was filtered, the filtrate was diluted with EtOAc and water, EtOAc layer was separated and the aqueous layer was further extracted with EtOAc, organic layers were combined, dried over Na2SO4, and was concentrated in vacuo to provide ethyl 2-(6-amino-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetate (0.2 g, 31%).

1. temperatureat reflux for 2 h
2. filtrationthe black mixture was filtered
3. additionthe filtrate was diluted with EtOAc and water, EtOAc layer
4. customwas separated
5. extractionthe aqueous layer was further extracted with EtOAc, organic layers
6. dry with materialdried over Na2SO4
7. concentrationwas concentrated in vacuo