反应详情

To a solution of ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate (0.23 g, 0.70 mmol) in a mixture of tetrahydrofuran (4 mL) and water (1 mL) was added lithium hydroxide (0.15 g, 3.51 mmol). The reaction mixture was stirred at ambient temperature for 18 hours and acidified to pH=6 with acetic acid. The white solid precipitated was collected by filtration, washed with water and dried in air to afford the title compound as a white solid (0.20 g, 95%): MS (ES+) m/z 301.2 (M+1).

1. customThe white solid precipitated
2. filtrationwas collected by filtration
3. washwashed with water
4. customdried in air