反应详情

To a solution of ethyl 2-(1-(2,2-difluoro-2-phenylethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate (0.13 g, 0.34 mmol) in a mixture of tetrahydrofuran (8 mL) and water (2 mL) was added lithium hydroxide monohydrate (0.05 g, 1.24 mmol). The reaction mixture was heated to reflux for 17 hours. The solvent was removed in vacuo, and the residue was neutralized to pH 4˜5 with 10% hydrochloric acid. The resulting precipitate was collected by filtration and dried to afford the title compound as a white solid (0.10 g, 84%): MS (ES+) m/z 349.1 (M+1).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 17 hours
3. customThe solvent was removed in vacuo
4. filtrationThe resulting precipitate was collected by filtration
5. customdried