Benzyl 2-aminoacetate hydrochloride → HCID 131729934, compound

HRID 2381888Notes

Reaction equation

HRID 2381888 reaction equation
NCC([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=O.Cl.C1C([NH:20][C:21]([C:23](O)=[O:24])=O)=CC=C([N+](O)=O)C=1.[NH2:29][C@H:30]([C:50]([OH:52])=[O:51])[CH2:31][CH2:32][CH2:33][CH2:34][N:35]([C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37]>CN(C=O)C>[CH2:6]([O:5][NH:20][CH2:21][C:23]([NH:29][C@H:30]([C:50]([OH:52])=[O:51])[CH2:31][CH2:32][CH2:33][CH2:34][N:35]([C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])=[O:24])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 11701227Benzyl 2-aminoacetate hydrochlorideHCID 178453398HCID 178453398, compound

Product 1

HCID 131729934HCID 131729934, compoundYield 105%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a magnetically stirred solution of H-Gly-OBn.HCl (2.50 g, 12.4 mmol) in DMF (80 ml) was added TEA (4.4 ml, 31.0 mmol) followed by PNPO-Lys(Boc)2 (6.96 g, 14.9 mmol). The reaction and product isolation were carried out according to the method of Example 72.i to give BnO-GlyLys[Boc]2 as a pale yellow foam (6.42 g, 105%).

Workup

  1. customThe reaction and product isolation

Sources & evidence

ORD record
ord-05def70a594f4321a1a41c7762dd1350
Source dataset
uspto-grants-2012_09
Patent number
US08258259B2

Reaction notes

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