HCID 58869858, compound → HCID 11673374, compound

HRID 2382162Notes

Reaction equation

HRID 2382162 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][N:13]=2)[CH2:8][CH2:7]1)[CH3:2].[H][H]>C1COCC1.[Pd]>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][N:13]=2)[CH2:8][CH2:7]1)[CH3:2]

Participants

5

Reactant 2

HCID 58869858HCID 58869858, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 11673374HCID 11673374, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of intermediate (1) (0.0102 mol) in THF (50 ml) was hydrogenated with palladium on carbon (10%; 0.3 g) as a catalyst for 30 minutes at a temperature of 50° C. After uptake of hydrogen (1 equivalent), the catalyst was filtered off and the filtrate was evaporated, yielding (5′-amino-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-acetic acid ethyl ester (intermediate 2).

Workup

  1. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-975e09f4dc974a49b59ba613a9722e95
Source dataset
uspto-grants-2012_09
Patent number
US08258304B2

Reaction notes

Loading…