反应详情

To a solution of methyl 2-(3-(phenyl(m-tolyl)methyl)pyrrolidin-1-yl)acetate (1.5 g, 4.64 mmol) in THF at 0° C. was added a solution of lithium hydroxide (0.58 g, 13.8 mmol) in water and the reaction mixture was stirred for 4 h. The reaction mixture was concentrated under reduced pressure. To the residue was added water, the pH of the aqueous layer was adjusted to 3 using dil.HCl and extracted with 30% methanol in chloroform. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 0.72 g of the title compound.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionTo the residue was added water
3. extractionHCl and extracted with 30% methanol in chloroform
4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure