Trifluoroacetic acid → HCID 68776068, compound

HRID 2382253Notes

Reaction equation

HRID 2382253 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]([CH3:24])[C:8]([NH:10][C:11]1[CH:23]=[CH:22][C:14]([C:15]([O:17]C(C)(C)C)=[O:16])=[CH:13][CH:12]=1)=[O:9].C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]([CH3:24])[C:8]([NH:10][C:11]1[CH:23]=[CH:22][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=1)=[O:9]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67128323HCID 67128323, compound

Product 1

HCID 68776068HCID 68776068, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the above ester in DCM (26 mL) was added TFA (8.7 mL) and stirred at room temperature. After 3 hours, the reaction mixture was concentrated and treated with Et2O. The solid formed was then filtered and washed with ether and dried to give 4-(2-(2-oxopyrrolidin-1-yl)propanamido)benzoic acid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. additiontreated with Et2O
  3. customThe solid formed
  4. filtrationwas then filtered
  5. washwashed with ether
  6. customdried

Sources & evidence

ORD record
ord-1ed0b8dbe105435ab51bc1546ce2af95
Source dataset
uspto-grants-2012_09
Patent number
US08258316B2

Reaction notes

Loading…