Diisopropylethylamine → HCID 66992137, compound

HRID 2382314Notes

Reaction equation

HRID 2382314 reaction equation
[C:1]([C:4]1([CH3:26])[C:9]([NH2:10])=[CH:8][C:7]([C:11](N2C3C(=CC=CC=3)C(C)CC2(C)C)=[O:12])=[CH:6][CH2:5]1)(=[O:3])[CH3:2].[C:27]1([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:32]=[CH:31][C:30]([C:33](Cl)=[O:34])=[CH:29][CH:28]=1.[CH:42]([N:45](CC)[CH:46]([CH3:48])[CH3:47])([CH3:44])[CH3:43]>O1CCCC1>[C:1]([C:4]1([CH3:26])[C:9]([NH:10][C:33](=[O:34])[C:30]2[CH:31]=[CH:32][C:27]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)=[CH:28][CH:29]=2)=[CH:8][CH:7]([C:11]([C:5]2[C:42]([CH3:43])([CH3:44])[NH:45][C:46]3[C:47]([C:6]=2[CH3:7])=[CH:4][CH:1]=[CH:2][CH:48]=3)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 841514-Phenylbenzoyl chlorideHCID 66992168HCID 66992168, compound

Product 1

HCID 66992137HCID 66992137, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Acylation of 1-acetyl-6-amino-4-toloyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (10 mg) with 4-biphenylcarbonyl chloride (14 mg) and N,N-diisopropylethylamine (20 l) in tetrahydrofuran (1 ml) was performed according to the method described in example 6.

Sources & evidence

ORD record
ord-f555416a78834f2ca7fe87e59b18108a
Source dataset
uspto-grants-2012_09
Patent number
US08258293B2

Reaction notes

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