Potassium Fluoride → HCID 57436858, compound

HRID 2382537Notes

Reaction equation

HRID 2382537 reaction equation
[C:1]([C:5]1[CH:35]=[CH:34][C:8]([CH2:9][S:10][C:11]2[O:12][C:13]3[C:18]([C:19](=[O:22])[C:20]=2[CH3:21])=[C:17](OS(C2C=CC(C)=CC=2)(=O)=O)[CH:16]=[CH:15][CH:14]=3)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[F-:36].[K+]>C1COCC1>[C:1]([C:5]1[CH:35]=[CH:34][C:8]([CH2:9][S:10][C:11]2[O:12][C:13]3[C:18]([C:19](=[O:22])[C:20]=2[CH3:21])=[C:17]([F:36])[CH:16]=[CH:15][CH:14]=3)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 522689Potassium FluorideHCID 57558439HCID 57558439, compound

Product 1

HCID 57436858HCID 57436858, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-(4-tertbutylbenzylmercapto)-3-methyl-5-tosyloxy chromen-4-one (200 mg, 0.39 mmol) is dissolved in THF in a 15 mL round bottom flask and potassium fluoride (0.39 mmol) and Kryptofix (0.39 mmol) are added to it. The solution is heated to reflux for 3 hours after which it is cooled to room temperature. The reaction mixture is then concentrated and the crude residue obtained is purified by silica gel flash chromatography to obtain the above product.

Workup

  1. temperatureThe solution is heated
  2. temperatureto reflux for 3 hours after which it
  3. concentrationThe reaction mixture is then concentrated

Sources & evidence

ORD record
ord-d9232741a4fb45469311b2f42dc0d01d
Source dataset
uspto-grants-2012_09
Patent number
US08263042B2

Reaction notes

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