反应详情

8-Benzyl-3-phenyl-8-aza-bicyclo[3.2.1]octan-3-ol (0.24 g, 0.84 mmol) was dissolved in IMS (4.5 mL) and water (0.5 mL). Ammonium formate (0.5 g) and Pearlman's catalyst (0.12 g) were added. The mixture was heated to reflux for 0.5 hour, filtered and the solution concentrated to give an oil which was purified by chromatography on an SCX cartridge eluting with ammonia (2 M) in methanol. The fractions containing the desired product were concentrated under vacuum to give the title compound (0.13 g) as an oil.

1. temperatureThe mixture was heated
2. temperatureto reflux for 0.5 hour
3. filtrationfiltered
4. concentrationthe solution concentrated
5. customto give an oil which
6. customwas purified by chromatography on an SCX cartridge
7. washeluting with ammonia (2 M) in methanol
8. additionThe fractions containing the desired product
9. concentrationwere concentrated under vacuum