Hydrochloric Acid → HCID 68725603, compound

HRID 2382598Notes

Reaction equation

HRID 2382598 reaction equation
Cl.C(OC(=O)[NH:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH:13]([NH:16][S:17]([C:20]2[CH:25]=[C:24]([C:26]3[C:27]([CH3:33])=[N:28][C:29]([NH2:32])=[N:30][CH:31]=3)[CH:23]=[CH:22][C:21]=2[Cl:34])(=[O:19])=[O:18])[CH2:12][CH2:11]1)(C)(C)C>O1CCOCC1>[NH2:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH:13]([NH:16][S:17]([C:20]2[CH:25]=[C:24]([C:26]3[C:27]([CH3:33])=[N:28][C:29]([NH2:32])=[N:30][CH:31]=3)[CH:23]=[CH:22][C:21]=2[Cl:34])(=[O:19])=[O:18])[CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68725929HCID 68725929, compound

Product 1

HCID 68725603HCID 68725603, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

4M HCl in dioxane (1.2 ml) is added to a stirred solution of {4-[5-(2-amino-4-methyl-pyrimidin-5-yl)-2-chloro-benzenesulfonylamino]-cyclohexylmethyl}-carbamic acid tert-butyl ester (Example 3-17) (0.25 g, 0.49 mmol) in dioxane (1 ml). After 18 h the solvent is removed to give the title compound.

Workup

  1. customAfter 18 h the solvent is removed

Sources & evidence

ORD record
ord-ef2e9dc8066048518518c2cb1c4d849d
Source dataset
uspto-grants-2012_09
Patent number
US08263585B2

Reaction notes

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