反应详情

温度

90 °C

8-Benzyl-3-phenyl-8-aza-bicyclo[3.2.1]oct-2-ene (0.1 g) was dissolved in IMS (5 mL) and water (0.5 mL). Ammonium formate (0.21 g) and Pearlman's catalyst (0.02 g) were added and the mixture heated to 90° C. for 1 hour. After cooling, the mixture was filtered and concentrated under vacuum. The residue was purified on an SCX cartridge, eluting with aqueous ammonia (2 M) and methanol. The fractions containing the desired product were concentrated under vacuum to give the title compound as a colourless oil. LCMS m/z 188.4 [M+H]+. R.T.=2.22 min (Analytical Method 4).

1. temperatureAfter cooling
2. filtrationthe mixture was filtered
3. concentrationconcentrated under vacuum
4. customThe residue was purified on an SCX cartridge
5. washeluting with aqueous ammonia (2 M) and methanol
6. additionThe fractions containing the desired product
7. concentrationwere concentrated under vacuum