反应详情

4-Phenyl-piperidine-4-carboxylic acid (1.0 g, 2.7 mmol) was added to a solution of borane in THF (1 M, 15 mL). The mixture was then heated at reflux for 1 hour, and then methanol (3 mL) was carefully added dropwise. The mixture was heated at reflux for 1 hour and allowed to cool to room temperature and hydrochloric acid (1 N, 2 mL) was added and the mixture left to stand overnight. The solvent was then removed by evaporation under vacuum and the residue triturated with acetone. The resulting solid was isolated by filtration, washed with diethyl ether and dried under vacuum to afford the title compound as a white solid (0.37 g). LCMS m/z 192.2 [M+H]+. R.T.=0.69 min (Analytical Method 4).

1. temperatureThe mixture was then heated
2. temperatureat reflux for 1 hour
3. temperatureThe mixture was heated
4. temperatureat reflux for 1 hour
5. waitthe mixture left
6. customThe solvent was then removed by evaporation under vacuum
7. customthe residue triturated with acetone
8. customThe resulting solid was isolated by filtration
9. washwashed with diethyl ether
10. customdried under vacuum