反应详情

ω-Bromoacetophenone (9.04 g, 45 mmol) and NaHCO3 (4.30 g, 50 mmol) were added to a solution of 4,6-diaminopyrimidine (5.00 g, 0.45 mmol) in methanol (80 ml), and the mixture was heated to reflux (3 h). Upon cooling, water (40 ml) was added, and the suspension was stirred at r.t. (15 min). The precipitated title compound (5.62 g, 59%) was isolated by filtration, washed with small amounts of water and methanol, and dried under vacuum. MS (m/e)=211.1 [M+H+].

1. temperaturethe mixture was heated
2. temperatureto reflux (3 h)
3. temperatureUpon cooling
4. customThe precipitated title compound (5.62 g, 59%)
5. customwas isolated by filtration
6. washwashed with small amounts of water and methanol
7. customdried under vacuum