Triethylamine → HCID 57477196, compound

HRID 2382759Notes

Reaction equation

HRID 2382759 reaction equation
Cl.[N:2]1[N:3]=[CH:4][N:5]2[CH2:10][CH2:9][NH:8][CH2:7][C:6]=12.C[CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15].[CH3:18]C(OC(OC(OC(C)(C)C)=O)=O)(C)C>C(Cl)Cl>[N:13]1([CH2:12][C:4]2[N:5]3[CH2:10][CH2:9][NH:8][CH2:7][C:6]3=[N:2][N:3]=2)[CH2:16][CH2:17][CH2:18][CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 90495Di-tert-butyl dicarbonateHCID 17998717HCID 17998717, compound

Product 1

HCID 57477196HCID 57477196, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (1.0 g, 6.23 mmol) in CH2Cl2 (25 mL) were added Et3N (2.17 mL, 15.57 mmol) and Boc2O (1.52 mL, 6.54 mmol) and the reaction was stirred at room temperature overnight. The mixture was extracted with aqueous 0.25 M KHSO4 (50 mL). The organic layer was dried (Na2SO4) and evaporated to dryness to afford compound A48-1 (1.29 g, 92%).

Workup

  1. extractionThe mixture was extracted with aqueous 0.25 M KHSO4 (50 mL)
  2. dry with materialThe organic layer was dried (Na2SO4)
  3. customevaporated to dryness
  4. customto afford compound A48-1 (1.29 g, 92%)

Sources & evidence

ORD record
ord-486f946f643a4bca995943b015ae68ed
Source dataset
uspto-grants-2012_09
Patent number
US08263598B2

Reaction notes

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