2-Amino-6-chloropyridine → HCID 59437545, compound

HRID 2382764Notes

Reaction equation

HRID 2382764 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.C([C:11]1[CH:15]=[CH:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[C:12]=1B(O)O)C>>[NH2:1][C:2]1[N:3]=[C:4]([C:12]2[N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:14]=[CH:15][CH:11]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 2062462-Amino-6-chloropyridineHCID 68485323HCID 68485323, compound

Product 1

HCID 59437545HCID 59437545, compound

Procedure

The title compound was prepared following procedure described for intermediate A1 step a), but starting from 2-amino-6-chloropyridine (2.05 g; 16.0 mmol; 1.0 eq.) and ethyl 1-(t-butoxycarbonyl)pyrrole-2-boronic acid (5.06 g; 24.0 mmol; 1.5 eq.) as a beige powder (1.15 g, 27%). HPLC, Rt: 2.65 min. (purity 97.0%). LC/MS, M+(ESI): 204.3.

Sources & evidence

ORD record
ord-18dc9945ca894473a9070a0be6ed4d5a
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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