Hydrochloric Acid → HCID 25212518, compound

HRID 2382780Notes

Reaction equation

HRID 2382780 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[C:9]([NH2:11])[N:10]=2)[CH:7]=1.Cl.[C:13]([Cl:21])(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[N:16][CH:15]=1.Cl>>[ClH:21].[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[C:9]([NH:11][C:13](=[O:20])[C:14]3[CH:19]=[CH:18][CH:17]=[N:16][CH:15]=3)[N:10]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 252159406-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25212518HCID 25212518, compound

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 6-bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A5), 5.0 g; 23.5 mmol; 1.0 eq.) and nicotinoyl chloride hydrochloride (5.01 g; 28.2 mmol; 1.2 eq.) as a light yellow solid (6.30 g; 84%). HPLC, Rt: 1.32 min. (purity 99.6%). LC/MS, M+(ESI): 317.9. CHN analysis: [C12H8N5OBr.1.0 HCl.1.0 H20] Corrected: C, 38.68%; H, 2.98%; N 18.80%. Found: C, 38.76%; H, 3.11%; N, 18.66%.

Sources & evidence

ORD record
ord-b480a7556fb74005b4393b5705557c67
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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