Pyrrolidine → HCID 59437435, compound

HRID 2382815Notes

Reaction equation

HRID 2382815 reaction equation
Br[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[NH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1>>[N:20]1([C:2]2[N:7]3[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]4[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=4)[N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 25212514N-(5-bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide

Product 1

HCID 59437435HCID 59437435, compound

Procedure

The title compound was prepared following procedure and work up described for example 30, but starting from N-(5-bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide ((B2), 50 mg; 0.16 mmol; 1.0 eq.) and pyrrolidine (1 mL) as a white solid (1 mg, 2%). HPLC, Rt: 1.81 min. (purity 97.3%). LC/MS, M+(ESI): 309.4, M−(ESI): 307.4.

Sources & evidence

ORD record
ord-82b1014aeff94b8a8f9d2e4bc01b54d4
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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