反应详情

1.34 g (3.581 mmol) of the product from Example 2A and 538 μl (3.581 mmol) of 2,4-dimethoxybenzylamine are dissolved in 40 ml of dichloroethane, and the mixture is stirred at room temperature for one hour. 1.52 g (7.162 mmol) of sodium triacetoxyborohydride and 820 μl (14.33 mmol) of glacial acetic acid are then added. The reaction mixture is stirred at room temperature for 15 hours. A saturated sodium bicarbonate solution is then added, and the product is extracted with dichloromethane. The organic extract is washed with water and dried over anhydrous sodium sulphate. After filtration, the solvent is removed on a rotary evaporator. The crude product is dried under high vacuum and used without further purification in the next reaction. What is obtained are 1.89 g of the title compound.

1. stirringThe reaction mixture is stirred at room temperature for 15 hours
2. extractionthe product is extracted with dichloromethane
3. extractionThe organic extract
4. washis washed with water
5. dry with materialdried over anhydrous sodium sulphate
6. filtrationAfter filtration
7. customthe solvent is removed on a rotary evaporator
8. dry with materialThe crude product is dried under high vacuum
9. customused without further purification in the next reaction
10. customWhat is obtained