反应详情

温度

90 °C

To a solution of 2-(4-bromophenyl)ethanol (48.3 g) in acetonitrile (480 mL) was added diisopropylethylamine (46.6 g), N-vinylphthalimide (43.7 g) and tri-o-tolylphosphine (7.31 g) and the mixture was purged with nitrogen gas three times. Palladium acetate (2.7 g) was added and the mixture was stirred at 90° C. for 21 hr under nitrogen. The reaction was cooled and the precipitated product collected by filtration. The resulting solid was re-dissolved in dichloromethane and ethyl acetate and filtered through silica gel. The filtrate was concentrated in vacuo to give the title compound, 24 g.

1. customthe mixture was purged with nitrogen gas three times
2. additionPalladium acetate (2.7 g) was added
3. temperatureThe reaction was cooled
4. filtrationthe precipitated product collected by filtration
5. dissolutionThe resulting solid was re-dissolved in dichloromethane
6. filtrationethyl acetate and filtered through silica gel
7. concentrationThe filtrate was concentrated in vacuo