反应详情

Under cooling in an ice bath, 2,2-dimethyl-1-propanol (1.55 g) was added to a chloroform (20 mL) solution that contained 3-bromobenzenesulfonyl chloride (3.00 g) and pyridine (1.86 g), and the obtained solution was then stirred at a room temperature for 60 hours. Thereafter, water and a saturated sodium hydrogencarbonate aqueous solution were added to the reaction solution, and the obtained mixture was then extracted with chloroform. The organic layer was washed with a saturated saline, and was then dried over anhydrous sodium sulfate, followed by vacuum concentration. The obtained solid was washed with n-hexane, so as to obtain the title compound (3.90 g) in the form of a colorless solid.

1. temperatureUnder cooling in an ice bath
2. extractionthe obtained mixture was then extracted with chloroform
3. washThe organic layer was washed with a saturated saline
4. dry with materialwas then dried over anhydrous sodium sulfate
5. concentrationfollowed by vacuum concentration
6. washThe obtained solid was washed with n-hexane